proprotein convertases การใช้

• The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products.
• First, proprotein convertases cut the precursor at specific sites to generate intermediates containing C-terminal basic residues ( lysine and / or arginine ).
• Several proteins within the pathway require either Ca 2 + ions, Mn 2 + ions, or divalent ions to function as aminopeptidase P, Proprotein convertases and sulfotransferases.
• As with many proteins, PCSK9 is inactive when first synthesized, because a section of peptide chains blocks their activity; proprotein convertases remove that section to activate the enzyme.
• Furin-like proprotein convertases ( PPC ) are responsible for conversion of 50 kDa HJV to a 40 kDa protein with a truncated COOH-terminus, at a conserved polybasic RNRR site.
• For some peptides, additional processing steps, such as C-terminal amidation, are subsequently required to generate the bioactive peptide, although for many peptides the action of the proprotein convertases and CPE is sufficient to produce the bioactive peptide.